Why the Five-Eyes Alliance sees Zero Trust as the best defense against agentic AI threats

Five Eyes agencies warn that agentic AI—capable of autonomously executing actions and interacting with systems—introduces significant cybersecurity risks if granted broad permissions. The guidance recommends applying existing Zero Trust controls (least privilege, deny-by-default, segmentation, continuous authentication, and application containment) to limit AI agent capabilities and highlights ThreatLocker features (application allowlisting, Ringfencing™, privileged access management, ZTNA, and Zero Trust cloud access) as practical mitigations.